A Concise Synthesis of Carolacton
نویسندگان
چکیده
A synthesis of carolacton, a myxobacterial natural product that has profound effects on Streptococcus mutans biofilms, is reported. The synthesis proceeds via a longest linear sequence of 14 steps from an Evans β-ketoimide and enabled preliminary evaluations of the effects of late-stage intermediates on S. mutans biofilms. These studies suggest that further investigations into carolacton's structure-function relationships are warranted.
منابع مشابه
Synthesis of new carolacton derivatives and their activity against biofilms of oral bacteria.
Carolacton, a secondary metabolite isolated from the extracts of Sorangium cellulosum, causes membrane damage and cell death in biofilms of the caries- and endocarditis-associated bacterium Streptococcus mutans. Here, we report the total synthesis of several derivatives of carolacton. All new structural modifications introduced abolished its biological activity, including subtle ones, such as i...
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Correction After publication of the original article [1] it came to the publishers attention that one name had been inadvertently misspelt. The correct authors' list should read as indicated above. We apologize for any inconvenience this has caused. and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton. v...
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